High-Risk Childhood Acute Lymphoblastic Leukemia
نویسندگان
چکیده
منابع مشابه
JAK mutations in high-risk childhood acute lymphoblastic leukemia.
Pediatric acute lymphoblastic leukemia (ALL) is a heterogeneous disease consisting of distinct clinical and biological subtypes that are characterized by specific chromosomal abnormalities or gene mutations. Mutation of genes encoding tyrosine kinases is uncommon in ALL, with the exception of Philadelphia chromosome-positive ALL, where the t(9,22)(q34;q11) translocation encodes the constitutive...
متن کاملAssocition between LAPTM4B gene polymorphism and the risk of childhood acute lymphoblastic leukemia
Introduction: Evidence suggests that Lysosome associated protein transmembrane 4B (LAPTM4B) contributes to the risk of numerous cancers. The present study aimed to find out the impact of LAPTM4B polymorphism on the risk of childhood acute lymphoblastic leukemia (ALL) in the southeastern Iranian population. Materials and Methods: A total of 230 subjects including 110 children diagnosed with ALL ...
متن کاملPresenting Clinical and Laboratory Data of Childhood Acute Lymphoblastic Leukemia
Abstract Background Leukemia is the most prevalent childhood cancer and Acute Lymphoblastic Leukemia (ALL) constitutes 75% of all cases. The most frequent presenting symptoms are fever, weight loss and pallor. Early detection of clinical symptoms positively affects timely diagnosis. The objectives of the present study were to assess frequency of presenting symptoms, laboratory data, immune ph...
متن کاملChildhood Acute Lymphoblastic Leukemia.
The cure rate for childhood acute lymphoblastic leukemia (ALL) now exceeds 70%. This success has been achieved in part by improvements in the biologic characterization of newly diagnosed patients. Modern treatment protocols rely on this information to tailor therapy to a patient's risk of relapse. Patients with favorable genetic features, such as hyperdiploidy or the TEL-AML1 fusion, can be tre...
متن کاملChildhood Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia (ALL) is recognized as a fast-developing cancer originated from blood-progenitor cells. Blasts cells are immature cells which generate white blood cells (leukocytes), and it is the malignancy of the blast cells which lead to leukemias. The bone marrow is gradually filled up with these blasts and as a result, the production of healthy blood cells will be damaged. Mal...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Lymphoma and Myeloma
سال: 2009
ISSN: 1557-9190
DOI: 10.3816/clm.2009.s.016